Python + Raylib comes in two flavors:

You can use the regular C-like raylib library, or you can use the pythonic version called "pyray".  It's a simpler version that builds on top of raylib.

Is there a preference on which to use? I was planning to make my game in pyray + python, but I wasn't sure if it's in the spirit of the jam. 

Thanks! 

Can it be compiled to WebAssembly to run on Web? It’s one of the requirements for the delivery

Yes! It can be ran on the web. Pyray uses pygbag for that: https://pypi.org/project/pygbag/ 

Here's a link to some documentation too: https://electronstudio.github.io/raylib-python-cffi/README.html#platforms-window...