I will not apologize for the title.

So, I'm wondering what locks you out of certain paths and who is mutually exclusive. I read the PDF that comes with the game but I'm still unsure.

Abby can confess to you pretty early, and it replaces her in camp dialogue. Do you have to accept or shoot her down? If you accept her, does that lock out of of everyone else except Arci? 

Vespa looks very similar to Abby.

Does "staying single" for Nell until she asks mean you can't date anyone else? If you accept her, similar question, are you locked out from everyone but Anya?

I would like to not be locked out of as much content as possible in a first play through, so that's my main goal! plus, forcing by bi ass to choose?smh

If I recall correctly:

Arci has to be done first, and then you can talk to her about having an open relationship, which allows you to date someone else. Claire can then date one more person, but ONLY one, among the several PCs and NPCs. I would recommend saving on multiple files to see the various unique mini-quests for each option, if you're that interested in them