This is a very cool take on the survivor style. Splitting the screen between the automatic/idle part and the POE talent tree works perfectly.
Visuals are top notch, I love the evolving Jeff on the left side. The whole feels cohesive and perfectly adequate with the theme of the game.
You mentioned not having your usual sound designer for this jam but it still does sound great!
The most important is that it feels fun. This is the first game jam project of this year that I gladly replayed multiple times just to try new talent paths and because it feels good.
I think this is overall a great game, especially for a jam concept. With a bit more polish, more balancing, it really could be a good buy as a commercial game. I would be interested by it. Congratulations 🎉