I tried progressing for a while, but got stuck repeatedly and then gave up. Tried another character, got stuck at the same point (a few rounds in, either at the first boss or right after it). Tried the vampire now, same result.
I was confused by firepower and technomancy, they don't seem to belong with the rest.
There doesn't seem to be anything to master other than dodging bullets/mobs. The special abilities were underwhelming, and if they have a visible timer indication, I didn't see it - so I ended up almost never using them.
Every run felt much the same, I felt like the different gear/characters don't actually require different behaviors or generate different expectations.