Love the story and art, I did however find the writing a little dense. I would have liked a third major NPC from Bio-Syn if some space could be stolen from the other text blocks. The Gods-Blood stuff seems a little superfluous to me.

Very excited to read this one! Have you listened to Old Gods of Appalachia? Seems like it would be up your alley. 
First off, while I love the title page, you are sacrificing a lot of space and the other pages  are very text heavy. I had to zoom in to 150% to read it comfortably.
I really like the typewriter font but I found the white on red very difficult to read. 
I'm a little unclear who Reuben is in the context of this community/setting besides the person who found the Ichor. A recently arrived mining company owner? I think a clarification when he is first mentioned "REUBEN MOSS, owner of Miners Inc who recently arrived to look for Ichor, has hired". Obviously, that's a clunky example, I'm sure there's a better wording. 
Same with Father Joseph. "Those gripped by REVELATION IIÍ-- most have been ripped from the guidance FATHER JOSEPH. " should this be "the guidance of Father Joseph" or "by Father Joseph".  On first pass I assumed Father Joseph was intentionally having people go made with divine revelation but as I get further in I think maybe it's the opposite. 
The first mention of the ABOMINATION caught me off guard as I thought I had missed something.  "If the ABOMINATION is released, he faces it and is killed." This makes it sound like it's a monster but the later description makes it sound like an illness. Also, unless I'm missing something, the Abomination Stats section doesn't have stats in it?

Love the art of the gang at the bottom of page two.  I'm unclear what the building is supposed to be in the Reuben Moss section. 

Overall, I love the setting, I see how this could be a ton of fun to play and it comes through you all had a great time creating this. A lot of the language around the religious stuff works really well and the unexplored revelations was very tantalizing.  I think taking a step back to establish what is the key pieces of information a Warden would need and making sure those are clearly communicated early on would go a long way. Maybe because this is like 30th module I've read, in the last two weeks, and many contained evil corp science experiments, but the Bio-syn stuff is less interesting and original to me than the religious and mining.  I think cutting the bio tech company,  expanding on the religious and mining elements would make this thematically stronger and more cohesive and simplify things to improve the utility. Alternatively, you could turn the secret lab into the mine and making Abomination into Ichor overexposure and I think it would streamline things.

Great job!

Art: Well-illustrated and aside from the stat boxes, one of the more readable examples of typography I've seen this jam. Could use maybe a little more color or, if sticking to black and white, some larger swathes of black to create visual structure. That said, it is thoughtful even in its minimalism and avoids looking like a basic Word doc, which is usually the danger when people opt for black-on-white throughout. Wrapping the text around the headers was an effective choice although "REUBEN MOSS" is a bit too long for that and maybe could be just "REUBEN" there.

Writing: I get the strong impression that there was a time crunch. As someone who edits for a living, this looks to me like a talented writer who was rushing and didn't edit themselves. There are typos as others have mentioned, and some places where the information has some structure but others where it's a bit steam-of-consciousness. That said, I think there's an interesting story here and the style of writing is effective at establishing vibes. I think with some restructuring and careful editing it would end up a 5/5, but right now there are too many parts that read like preparatory notes, not a final draft.

Game Design: This is probably too ambitious for a trifold, mainly because the way the plot is designed, exploration of the facility is the central activity, but you envision five floors each with multiple locations. I do like the thought you gave to fleshing out the NPCs and potential plot arcs.

Theme: Full marks. Very mythology and very Mothership, and those two thematic axes are well-integrated throughout.

Layout: Mostly effective. I think some things could use a bit more padding and the sections of text that are in point form, like Joseph's story beats, should probably have bullets. As with the writing, I get the impression that you know how to do layout, but were probably operating under deadline panic, because there are some things that are done well and other things that aren't done at all. Finally, I know that people read pamphlets in different orders, but personally I go cover, flap, spread, back, so when the introductory overview is on the back, I end up confused and trying to piece things together as I go. I think the inner flap or left panel of the spread are the safest places for that stuff, because you're physically compelled to see them before fully opening and getting to the spread.

Utility: I have to give low marks here because of the combination of unfinished aspects and too sprawling a concept to fit effectively into a trifold. Unless the Warden is extremely good at environmental ad-libbing, you're asking them to sketch five level plans for themselves among other prep.

Favorability: Full marks here. I think it's thematically great and I appreciate ambition even if it didn't really come to fruition under space and deadline constraints.