Poor Lisandra :( also is the map missing? It's referenced a couple times, but I didn't see any file.
Mysteries are tough, especially when players are rolling to find clues because even "Easy" checks can be failed. Consider the three clue rule or similar, or make finding the right clue a matter of time. The consider, what happens to the party if they waste time?
I think you can provide the GM with a little more detail on the mystery and a little less detail on how to understand the underlines, italics, and bold. If you use less typographical iconography but keep it consistent, we can figure it out. That buys you some writing and layout space to give us more details on the NPCs and the mystery. Who really did it? Was it Lisandra and why frame her if you're going to sacrifice her? Or is she a cultist suffering on purpose? Why does Lisandra have Lycanthrope Suppressant? Where's the Mayor's dad? Is he still around? Does Nesåm deliver on their promise for prosperity from pain? There's so much mystery here and if I'm the GM, I want to know more!