Auto-pathing is kinda helpful if you clear an area out before more guys respawn, or if your dude is stuck in a building area you can use it to move around while farming more enemies.
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IF you clear an area before more mobs spawn, you should move on to a tougher area.
If you're in a "building area", which I assume you mean an enclosed space (which all environments are, btw) it is absolutely useless because you will be running from your opponents while taking hits from others and never fully killing anything that you could otherwise kill by standing still.
I played as a mage, which should get the most out of auto-pathing, but even to farm the Goblin Boss it was useless and actually made me die, when manually farming I never did.
So; maybe I'm not understanding what you're trying to say, or you're wrong.