Hi! It seems like there's a glitch. When I use the Escape menu, then exit the menu, I can't open it again (with the Escape key anyway). Thus, I can't save the game from that point.
This might be a coincidence, but after I lost access to the menu, I stopped being able to click to progress the dialogue. However the problem went away when I alt-tabbed out of the game, and back to it.