This is a very cute game. And it performs very well on my potato of a computer. Looks great. Sounds squelchy and adorable. Even a little funky.
The only small problems I have with it:
Mechanically, I don't understand why using the germ busting piece doesn't score anything. Seems as though we need points for destroying pieces, why not a flat +1 point per piece destroyed? Give the player something for using them if a proper wall-to-wall combo isn't available.
Flavorfully, I don't like the tutorial character defaulting to referring to the player as "boy." That's an assumption I'd like not to make on who is playing this game if it can be helped.