This is great feedback, thank you! I'm not the programmer on this, but I think I can speak to some of your points. I think there are some behaviors that are currently broken that we just ran out of time or didn't catch in the playtesting/bugfixing stage. So you may have done things correctly with an undesired result! The -68 actions is one I haven't seen before.
I don't think clicking the resource icon moves you to the lane currently, even though the UI behaves like it's a button. Skipping to a lane would be nice! The only way to change lanes at the moment is to use the up/down arrow keys on the keyboard or the up/down arrow buttons on the indicator on the left side.
The Soul Fragment gets revealed through regular progression, which you wouldn't get to if you're in this bugged negative actions state.
I think making the draw pile and discard pile for each lane clearer, even with a label would make things easier to parse.
The boons are specific to each god. While some are persistent, most follow the gods and apply the boon to the lane the god is on. I believe only one boons lets you pick a specific lane to apply the boon to, but we don't have anything that indicates that boon is applied. I think the UI in the bottom right with the boons acquired for a god can also name the god for those boons, which would also better communicate to the player who's who. It would also solidify the relationship between the physical form of the god on the main gameplay screen and the one that reveals itself to the player when selecting boons.
Maybe the "Draw Card" button should just say "Recruit Acolyte" or something to that effect instead. Draw card implies there's a mystery deck offscreen, when that's not what I think is happening.