This is a good game, but I've noticed a UI issue that starts to get a little more annoying the further you get in the game.
Whenever a drone/cargo ship or otherwise starts/ends its active mission, UI buttons will ignore/interrupt their mouse clicks on that specific frame (I assume its updating some UI element?), which isn't an issue when stuff has minutes of travel time and such. but when there are enough of them (and/or their journeys frequent and incredibly short) this does start to get noticeable. (such as tying level 3 engines on cargo ships and not using many hubs with their journeys super short and numerable).
Noticing this when I saw galactic knowledge is based on settled systems, so to get more you need to play longer and further in the system stage, which is when this starts to mount up considerably.