This game rocks! The mixed aesthetics of black and white anime girl and coloured pixel art was kind of jarring at first, but really grew on me and I think its very visually distinct. I think if you create just a little more opportunities to display specifically the black and white anime style in game, you're going to have a really unique and eye catching art style.
The progression and steady introduction of new mechanics (there were WAY more than I initially thought there would be) was perfectly paced in my opinion, and the enemy encounters (particularly the first one) were great gameplay wise - really fun to have to manage the visibility, sanity, health and distraction systems all at once. This kind of gameplay serves the horror genre SO well.
The story didn't engage me too much, however I did really like the whole Jeckel and Mr Hyde narrative dynamic. The way this also eventually transitioned into gameplay was also awesome. The level design and puzzles were really good too.
The crafting system was really interesting, although I do think you need to add a little more feedback for when the player actually crafts something. Even just the "craft" button changing colour or briefly flashing when you press it would make it clearer when you've crafted something.
My biggest piece of feedback would be to maybe make the crafting menu pause the game when you open it. I get what you were going for in keeping the tension by not having the game pause when the player opens their inventory, but I feel like it might be a little too harsh, especially as it forces the player to make decisions a little too quickly as well as not appreciate how impressive and interesting the crafting and inventory menus actually are.
Overall this game is really fun and has a lot of potential, keen to stay updated on future development and updates!