Love the themes, politics, and philosophies this game explores. My only issue is that it's a little too doomer, and it feels like a complete manifestation of hatred for modern life. You give very broad criticisms to several topics at once without giving everything the nuanced discussion it deserves. It's very important that the people playing your game fully understand why the things you criticize are bad, but you should also consider some of the good modernism has brought humanity.
For example, Big Pharma isn't bad because it produces and distributes antidepressants and ADHD meds. Those medications actually help A LOT of people, like myself. Big Pharma's crimes are using its vast wealth and resources to price gouge life-saving medicine, bribe/lobby doctors to over-prescribe, and bribe/lobby politicians to deregulate them. Also, Ozempic and its derivatives were not originally meant for weight-loss; they were meant to help diabetic people manage their appetites and blood sugar. There are definitely some people who genuinely need the drug for weight loss though. It's just super overprescribed. I don't think your criticisms here have as much to do with modernism as much as they do capitalism. The culture breeding Big Pharma's issues are a symptom of our economic system first and foremost.
Onto the more doomer themes.... It feels like you view the world as devoid of hope. It's a little disheartening and VERY depressing. I think it would help if you introduce more positive events that increase the likelihood of revolution, and it shouldn't be as easy to dismiss/bribe your way out of it. The populace has genuinely no chance of forming a revolution. The highest my percentage got was 37%, and it would provide a much more positive message to the player if the world could win.
If you have any questions, arguments, and/or think I may have misinterpreted your messaging, let me know. I gave a lot of criticisms, but I agree with the great majority of your messaging. Given the time crunch, I imagine there wasn't too much time to flesh everything out, and I think you did a great job on most things!