Whether the controls make sense without coaching
I completely skipped reading any instructions and just played. The connect-3 (or more) kind of games is very common.
Whether enemy intentions are understandable
Never got to understand the enemy - except the obvious of hurting me
Whether relic choices feel meaningful
Too much text and too unclear how they help.
Whether you actually want another run
Not exactly my type of game, but nevertheless, unfortunately no.
Need polish, feedback to player, cool animations & effects, sfx, clear method of learning skills by trying, powerups etc. as you play.
UI felt like web UI generated by Claude. Nothing wrong with it if it is - but IMO game UI should have its own appeal.
Hope that helps and no offense if a bit harsh.