I really liked the concept, the music is awesome, and the vibe is pretty sweet.
The painful part for me was 2D-3D switching, when you fail the platformer level and have to go around again to find another seed to try.
Thanks for very solid advice about purify water!
The only thing I have to add is that once you reach "karma farming" territory it's smart to avoid doing any karma-based purchases (or defer them until that wouldn't ruing the whole balance) for some time because having karma is incredibly helpful for being able to farm karma, i.e. what you named spam clicking prestige.